However, the molecular mechanisms involved are largely unknown 2 and progress in the field has been hindered by the combination of the paucity of suitable gametocyte-specific marker molecules, and the fact that only a small subset of asexual forms undergo differentiation to the sexual forms. The differentiation of a small proportion of the asexual blood-stage parasites into the transmissible sexual form (‘gametocytogenesis’) is a crucial ‘bottleneck’ step in the parasite life cycle, and in the transmission of the disease from one person to another 1. It is through the ingestion of gametocytes, in the course of the mosquito vector taking a blood meal, that the parasite is transmitted from its vertebrate to its invertebrate host. However, a small proportion differentiate into sexual, male or female, forms known as gametocytes. The majority of the intraerythrocytic parasites are asexual. In the course of its complex life cycle, the parasite invades the erythrocytes of its mammalian host. falciparum is the most virulent of the five species of malaria parasite known to infect humans and it accounts for the vast majority of the estimated 627,000 annual deaths from malaria ( ). Last year's march, the first after a two-year hiatus due to the coronavirus pandemic, drew hundreds of thousands of people, according to some estimates.Malaria is an infectious disease, caused by parasites of the genus Plasmodium and transmitted by the female Anopheles mosquito. On Saturday, supporters of LGBTQ+ rights are set to march down one of Mexico City's main avenues to the central square to raise awareness of violence and discrimination against the community and push for equality. The process, which is free in Mexico City, comes after legal reform in 2014 allowing adults to change their gender on birth certificates and electoral cards if they identify as a different gender from the one assigned at birth.

Transgender people face many hurdles when they cannot update legal documents such as ID cards to reflect their gender identity.

It took until last year, however, for the rest of the country to follow suit with Tamaulipas becoming the final state to do so in October.Īnother 131 people in the capital are set to complete administrative gender-change processes, the city government said.

In 2009, Mexico City became the first jurisdiction in Latin America to legalize same-sex marriage.

Play parasite in city stage 3